• Skip to main content
  • Skip to after header navigation
  • Skip to site footer
ERN: Emerging Researchers National Conference in STEM

ERN: Emerging Researchers National Conference in STEM

  • About
    • About AAAS
    • About the NSF
    • About the Conference
    • Partners/Supporters
    • Project Team
  • Conference
  • Abstracts
    • Undergraduate Abstract Locator
    • Graduate Abstract Locator
    • Abstract Submission Process
    • Presentation Schedules
    • Abstract Submission Guidelines
    • Presentation Guidelines
  • Travel Awards
  • Resources
    • Award Winners
    • Code of Conduct-AAAS Meetings
    • Code of Conduct-ERN Conference
    • Conference Agenda
    • Conference Materials
    • Conference Program Books
    • ERN Photo Galleries
    • Events | Opportunities
    • Exhibitor Info
    • HBCU-UP/CREST PI/PD Meeting
    • In the News
    • NSF Harassment Policy
    • Plenary Session Videos
    • Professional Development
    • Science Careers Handbook
    • Additional Resources
    • Archives
  • Engage
    • Webinars
    • ERN 10-Year Anniversary Videos
    • Plenary Session Videos
  • Contact Us
  • Login

Synthesis of 2-Acetylnaphtho[2,3b]furan-4,9-dione Toward The Exploration of Skin Cancer Cells and Normal Cells

Undergraduate #140
Discipline: Biological Sciences
Subcategory: Plant Research

Adria Peterkin - Howard University
Co-Author(s): Ponsawan Netcharoensirisuk and Wiranpat Karnsomwan, Chulalongkorn University, Bangkok, Thailand



After many years of developmental drug discovery, the most important modern medicine has been withdrawn from organic environments. Pharmacognosy has established it’s “roots” as the study/practice of cultivating medicinal drugs from natural resources such as plants. Not only does this provide a foundation for innovation, but also a cost efficient structure for developing countries. Avicequinone C is a compound extracted from an Indian Mangrove plant (Avicennia Marina), and its structure has been manipulated and reproduced in laboratories. The objective of this research is to synthesize Avicequinone C and it’s analogs, to manipulate treatment of Melanoma cells in order to isolate the complex polymer, melanin in hair follicles. This is done as a strategy to restrict melanin’s, transfiguration to Pheomelanin, a white pigment, in hair follicle’s. In this study, WNK-3 and WNK-4 were synthesized as a precursor to Avicequinone C. These compounds, along with previously synthesized compounds of WNK-1, WNK-5, WNK-6, and WNK-7 were then used to perform a cytotoxicity test on normal skin keratinocytes (HaCaT cell line), and Melanoma skin cancer (A375 cell line). The cytotoxicity of WNK-5 and its analogs are represented by IC50 values. This illustrates values of the substance concentration causing 50% inhibition (IC50) of the living cell. The results show that Avicequinone C (WNK-5) and its analogs have an affect on both skin cancer and normal skin cells. Moreover, WNK-4, the substrate to synthesized Avicequinone C (WNK-5), shows more toxic in cancer cells when compared with normal skin cells. Their IC50 values were computed at 8.094 μΜ and 17.531 μΜ respectively. The conclusions of this research are suggested to have a benefit in areas of cancer therapy, and can be used for basic information to further the study. Although these results have only undergone one trial of verification, the interpreted results reflect an important step forward toward the overall objective.

Funder Acknowledgement(s): GEAR-UP; NSF

Faculty Advisor: Ponsawan Netcharoensirisuk, nes.naka@hotmail.com

Role: The research I conducted was everything stated in the abstract.

Sidebar

Abstract Locators

  • Undergraduate Abstract Locator
  • Graduate Abstract Locator

This material is based upon work supported by the National Science Foundation (NSF) under Grant No. DUE-1930047. Any opinions, findings, interpretations, conclusions or recommendations expressed in this material are those of its authors and do not represent the views of the AAAS Board of Directors, the Council of AAAS, AAAS’ membership or the National Science Foundation.

AAAS

1200 New York Ave, NW
Washington,DC 20005
202-326-6400
Contact Us
About Us

  • LinkedIn
  • Facebook
  • Instagram
  • Twitter
  • YouTube

The World’s Largest General Scientific Society

Useful Links

  • Membership
  • Careers at AAAS
  • Privacy Policy
  • Terms of Use

Focus Areas

  • Science Education
  • Science Diplomacy
  • Public Engagement
  • Careers in STEM

Focus Areas

  • Shaping Science Policy
  • Advocacy for Evidence
  • R&D Budget Analysis
  • Human Rights, Ethics & Law

© 2023 American Association for the Advancement of Science