Discipline: Mathematics and Statistics
Sieu Tran - Virginia Tech
Co-Author(s): Jeremy Gunawardena, Harvard University, Boston, MA
We seek to understand how a single type of transcription factor regulates gene expression (in eukaryote) by studying the previously introduced linear framework-based model of the gene regulation function (GRF), which employs higher-order cooperativities of transcription factors (TFs) and DNA polymerase. We looked at whether it is possible to have multiple windows of ‘activation’ and ‘repression’ and the necessary mechanisms, such as numbers of sites or forms of higher-order cooperativity, to achieve such pattern.
Funder Acknowledgement(s): Javier Estrada, Kate Shulgina, and Janne Kool, Jeremy Gunawardena Department of Mathematics, Virginia Tech, Blacksburg, VA. Department of System Biology, Harvard Medical School, Boston, MA.
Faculty Advisor: Jeremy Gunawardena, firstname.lastname@example.org
Role: I have completed all of the results created in this studies. I did not create the mathematical frame-work, which this work is based on.