Discipline: Biological Sciences
Subcategory: Cell and Molecular Biology
Christelle Omeler - Oakwood University
Co-Author(s): Nakiah Gipson, Jaylon Vaughn, Terrance Platt, Soweto Thomas, Chasity Bradford
Cardiovascular Disease (CVD) is the leading cause of death in the United States and worldwide. Hypertension, one of the primary causes of CVD, is more prevalent in African Americans. These statistics are more alarming for the southern black belt region of the United States, where there is an increase in the African American population. Hypertension (high blood pressure) promotes the development of left ventricular hypertrophy (LVH). LVH is the enlargement of the left ventricle of the heart. Increased LVH causes an elevation of reactive oxidative species (ROS) which are free radicals that can damage cells structures and their functions. Antioxidants are a defense against ROS that is found naturally in the body or through dietary supplements. The antioxidants that will be studied are superoxide dismutase (SODs) which are found in different areas of the cell and stabilize or deactivate free radicals. Pumpkins have beta-carotene and vitamin C that are part of the antioxidant defense system. This will be done by looking at the enzymes found in the left ventricle through protein assay and western blotting. The purpose of this research is to look into the antioxidant defense in the extracellular of the left ventricle.
Funder Acknowledgement(s): National Science Foundation REU (DMR Award#1659506
Faculty Advisor: Chasity Bradford, email@example.com
Role: I did the methods portion of the research where I performed multiple protein assays, western blots, homogenization of the organs.