Discipline: Chemistry and Chemical Sciences
Subcategory: Chemistry (not Biochemistry)
Winston Odom - Morehouse College
Co-Author(s): Kwame Glinton and Brian Lawrence, Morehouse College Huw Davies, Emory University
Carbenes are widely used in C-H insertion and cyclopropanation reactions. These products can then be used in medicinal chemistry as potent treatments for neuropathic pain and cocaine addiction. The difficulty in C-H functionalization is achieving selective reactions. Many scientists approach the challenge of selective reactions by conducting the chemistry in an intermolecular fashion. The ultimate goal of this project is to explore the viability of these reaction products in the Rh2 catalyzed cyclopropanation of terminal olefins, such as styrene. The preparation of the 4-pyrimidine-1-methylsulfonyltriazole was successful, the % yield was below 50. The future goal is to utilize this 4-pyrimidine-1-methylsulfonytriazole to formulate a cyclopropane. More prospective research will be focused on novel substituent heteroaryl-N-sulfonyltriazoles. This research will enhance the chemistry community on how individuals perceive interchangeable ligands on 4-heteroaryl-Nsulfonyltriazoles.
Funder Acknowledgement(s): I wish to thank Dr. Embree and the SURE program. Dr. Lawrence and Dr. Davis for assisting me throughout my research. Also, CCHF for accepting me into the group.
Faculty Advisor: Brian Lawrence,