Discipline: Chemistry and Chemical Sciences
Subcategory: Cancer Research
Room: Exhibit Hall A
Dolapo I Nurudeen - Morgan State University
Co-Author(s): Angela Winstead, Morgan State University, Baltimore Maryland; Santosh Mandel, Morgan State University, Baltimore Maryland
Cancer is the abnormal growth of cells and its treatment may include chemotherapy, radiation, and surgery. Different chemotherapeutic drugs have been developed depending on the type of cancer, however, most of these drugs have severe side effect and drug resistance. For example, prolonged use of Tamoxifen, an anti-cancer drug effective on only estrogen receptor-positive breast cancer, has been linked to endometrial cancer. Due to the side effects of some of these cancer drugs, other alternatives are being researched such as organometallics rhenium compounds. Rhenium compounds are known to be nontoxic and exhibit no drug resistance. Previous studies in our lab have shown promising synthesis of a series of organometallic rhenium complexes bearing different α -diimine ligands. Specifically, this study examines the synthesis of an organometallic rhenium compound bearing α -diimine ligand 5, 6-dimethyl-1,10-phenanthroline. Re2(CO)10 is combined with 5,6-dimethyl-1-10-phenanthroline and CO2 and stirred for 30 minutes in a microwave vial. The vial was transferred to the CEMTM microwave and irradiated at 160⁰- 170° and the time varied from 2- 3 hours. The vial was stirred in CO2 and hexanes for an additional 23 hours. Subsequent filtration of the mixture afforded yellow particles of PC5. Multiple trials of this experiment were performed with different temperature and time to obtain an optimized yield of PC5. Different trials of this synthesis were repeated to obtain an optimized product that can be used for further studies. The trial with the lowest and highest microwave time provided products with the lowest yield and highest impurities content. An optimal and clean product was obtained at irritation temperature of 170⁰ and time of 3 hours. Infrared spectroscopy was done on all the samples to determine the trial that provided the product with the lowest impurity. The microwave synthesis of PC 5 for 3 hours and at 170 °C was successful because there was no starting material left in the final product and there was an increase in the optimal yield. Hence, this can be used for further studies on the product. Further studies to be performed is the reaction of PC5 with camphoric acid.
Funder Acknowledgement(s): I thank Dr. Angela Winstead and Dr. Santosh Mandal for their help. I also thank the Morgan State University Chemistry department for funding the research.
Faculty Advisor: Angela Winstead, Angela.firstname.lastname@example.org
Role: I did all part of the Research including the synthesis and IR characterization of the organorhenium complex bearing the ? -diimine ligand 5, 6-dimethyl-1,10-phenanthroline.