Discipline: Chemistry and Chemical Sciences
Subcategory: Chemistry (not Biochemistry)
Room: Exhibit Hall A
Khayra Alabrash - Morgan State University
Co-Author(s): Santosh Mandal Ph.D, and Angela Winstead, Ph.D; Department of Chemistry Morgan State University, 1700 E. Cold Spring Lane, Baltimore, MD 21251
Each year 12.7 million individuals learn they have cancer, and 7.6 million will die from it. Research shows that with proper treatment and early diagnosis, roughly 33% of cases can be cured and 30-40% of deaths can be prevented. Current cancer medications e.g. Tamoxifen, the leading drug for hormone receptor positive breast cancer patients, causes endometrial cancer as well as tumor drug resistance after long use. Due to the current drawbacks of current drugs, there is an urgent need to develop an alternative. Previous studies in our lab have shown promising cytotoxicity results for ibuprofen substituted rhenium pentylcarbonato complexes (PC) with IC50 values as low as 1.059?M, revealing their strong ability to act as anticancer agents. The current study examines the synthesis of ten additional ibuprofen substituted rhenium pentylcarbonato complexes. Ibuprofen substituted rhenium PC complexes are synthesized in a two-step synthesis: (1) microwave assisted organic synthesis of ten PC (fac-(CO)3(?-diimine)ReOC(O)OC5H11) derivatives (2) treatment of PCs with ibuprofen using traditional heating methods. Seven PC complexes have been successfully synthesized using microwave technology three of which are novel complexes. Re2(CO)10 is combined with a ?-diimine ligand and stirred CO2 for 30 minutes in a microwave vial. The vial is transferred to the CEMTM microwave and irradiated at 150-170?C for 2 – 4.5 hours. The optimized percent yields for the seven PC derivatives ranged from 75-85%. The yields using conventional heating are ranges from 66% – 83%, with reaction times ranging from 24-48 hours. An ibuprofen substituted rhenium PC derivative was synthesized in 2 hours resulting in a quantitative yield. Utilizing this method, seven precursors and one ibuprofen substituted complex were synthesized with shorter reaction times and higher yields.
Funder Acknowledgement(s): Acknowledgments: Funded by NSF-LSAMP grant number HRD-15031920008749.
Faculty Advisor: Dr. Angela Winstead, email@example.com
Role: All microwave synthesized complexes presented were completed by me.