Discipline: Biological Sciences
Subcategory: Cell and Molecular Biology
Myles Bartholomew - Xavier University of Louisiana
Co-Author(s): Hasahn Conway, Xavier University of Louisiana, New Orleans, Louisiana; Tajhshea Walden, Xavier University of Louisiana, New Orleans, Louisiana; Elise LeMelle, Xavier University of Louisiana, New Orleans, Louisiana; Syed Muniruzzaman Xavier University of Louisiana, New Orleans, Louisiana; Harris McFerrin Xavier University of Louisiana, New Orleans, Louisiana;
This project explores the practicality of implementing rare carbohydrates in combating angiogenesis as it relates to the progression of tumor formation. Both the implementation and physiological effect of rare carbohydrates have gone undiscovered, mostly due to the high production costs and low natural availability of the sugars. Despite hindrances, a method of producing the rare ketohexoses from glucose is now applicable and may lead the way to healthier foods and pharmaceuticals. The main objective of this study is to analyze the effect that rare ketohexoses have on angiogenesis and cell migration. The effect is observed via chick embryo CAM angiogenesis model and wound healing assay. In this study eight different ketohexoses were analyzed and two showed significant inhibition of angiogenesis and possible inhibition of cell migration. This data indicates these rare sugars could be used to prevent blood vessel growth in the context of cancer.
Not SubmittedFunder Acknowledgement(s): HEM: Louisiana Biomedical Research Network NIH NIGMS 8P20GM103424 (INBRE) SM: RCMI grant number 2G12MD007595-06. and NSF grant number 215903
Faculty Advisor: Syed Muniruzzaman, smuniruz@xula.edu
Role: My role in this work was application and data analysis. I used tissue culture and wound healing assays to elucidate the roles of the differnt rare Ketohexoses and their possible inhibition.