Discipline: Biological Sciences
Room: Exhibit Hall
Anthony Ervin - Dillard University
Co-Author(s): Benard Ogola, Ph.D., Tulane University, New Orleans, LouisianaSarah Lindsey, Ph.D., Tulane University, new Orleans, Louisiana
Hypothesis: If sex chromosome play a role in the female phenotype than XX females should be more susceptible to arterial stiffness than XY males.Importance: Sex as a biological variable plays an important role in cardiovascular disease.Arterial stiffness is a gradual change in the structural components of the vascular wall accompanied by a loss of compliance that negatively impacts cardiac function. Sex differences are noted in this pathology, with females being more susceptible to arteria stiffness as well as its impact on cardiac function. One potential cause of sex differences in genes that are expressed on the sex chromosomes is XX in females and XY in males. Using the Four Core Genotvpe mouse model, we can determine the impact of these different chromosomes on vascular and cardiac alterations.Methods and Controls: Left Ventricular function was assessed by echocardiography in the short axis. Intracarotid PWV (ic-PWV) was measured via ultrasound using the transit time method on the carotid artery.Results and Discussion: The results concluded that the Intracarotid PWV is not impacted by sex Chromosomes in gonad-intact animals, the % Ejection is impacted by sex chromosomes in gonad-intact animals, and the Left Ventricle is not impacted by sex chromosomes in gonad-intact animals. It demonstrates that the Four core genotype mouse model is an effective way of studying sex-linked diseases.Conclusion: Four core genotype mice can be used to study the role of sex chromosomes andsex hormones in CVD. A sex effect was indicated in % ejection fraction while LV mass was impacted by sex chromosomes only in male mice.Future Research: Future directions include using the four core genotype mouse model indifferent experiments to further improve its effectiveness. It will be used in cardiac research.Key Refrences:1. G protein-coupled estrogen receptor protects from angiotensin II-inducedincreases in pulse pressure and oxidative stress, Benard Ogola, TulaneUniversity, 2019.2. Sex Differences in Cardiovascular and Cerebrovascular Physiology, Disease,and Signaling Mechanisms: New insights into arterial stiffening: does sexmatter?, Benard Ogola, Tulane University, 2018.3. New insights into arterial stiffening: does sex matter?, Benard Ogola, TulaneUniversity, 2018.
Funder Acknowledgement(s): Acknowledgments: I would like to acknowledge my mentors at Tulane Dr. SarahLindsey and Dr. Benard Ogola. I thank them for their continued support of me and myfuture endeavors. I would also like to thank the advisor of the American HeartAssociation, Ms. Charlene Walton for partnering with such great research mentors. Iwould finally like to thank my student mentor, Joshua Hines, for recommending me forthe AHA HBCU Scholars Program.
Faculty Advisor: Dr. Ruby Broadway, Ph.D. U-RISE Program Director, firstname.lastname@example.org
Role: He took blood pressure of the mice, dissection of the heart arteries and measure the mice EKGs