Discipline: Biological Sciences
Subcategory: Cancer Research
Hasahn L. Conway - Xavier University of Louisiana
Co-Author(s): Kevin Lam, Elise LeMelle, Sydnie Turner, Syed Muniruzzaman, and Harris McFerrin, Xavier University of Louisiana
The practical application, usefulness and physiological effect of rare carbohydrates have not been well investigated because of initially high production costs and low natural availability. Despite these initial impediments to their study, rare ketohexoses can be produced systematically from inexpensive glucose and can be used to produce healthier foods or as pharmaceutical products. The main goal of this study was to determine the effect of rare ketohexoses on the process of angiogenesis in a in vitro migration assays model. Angiogenesis is the fundamental process by which new blood vessels are formed as extensions from the existing vasculature. In this study we have used eight different ketohexoses, out of these eight keto-hexoses, one has shown significant inhibition of angiogenesis. This inhibitory effect was also determined to be stereospecific as the D-isomer of the same sugar was significantly more effective than that of the L-isomer.
Funder Acknowledgement(s): HEM: Louisiana Biomedical Research Network NIH NIGMS 8P20GM103424 (INBRE) SM: RCMI grant number 2G12MD007595-06 and NSF grant number 215903.
Faculty Advisor: Harris Mcferrin and Syed Muniruzzaman,