Discipline: Chemistry & Chemical Sciences
Subcategory: STEM Research
Fenghai Guo - Winston Salem State University
Co-Author(s): Dynasty Parker, Shekinah Bass, and Tania Bellinger, Winston Salem State University
Carbon carbon bond formation reactions are important in that they provide key steps in building complex, bioactive molecules from simple starting materials. Conjugate addition reaction is one of the most reliable carbon carbon bond forming strategies. Conjugate addition reactions of N, S containing Michael acceptors with Organometallic reagents catalyzed by Copper salts, Zinc (II) salts are investigated in the synthesis of N-containing heterocycles, organosulfur compounds with rich bioactivities. Excellent yields of 1,4-adducts can be isolated (> 90%). The use of commercially available or easily prepared organometallic reagents will expedite the synthesis of a large library of these N-containing heterocycles, organosulfur compounds for further synthetic applications and biological studies.
Funder Acknowledgement(s): NSF HBCU-UP RIA (no. 1600987).
Faculty Advisor: None Listed,