Emerging Researchers National (ERN) Conference

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Theoretical Study of Cytosine Methyl Derivatives and N9H Guanine keto

Undergraduate #268
Discipline: Nanoscience
Subcategory: Nanoscience

Classie Bradford - Hinds Community College-Utica Campus
Co-Author(s): Terra Dorsey and Zarah Drake, Jackson State University, Jackson, MS


Today, researchers know that DNA methylation occurs at the cytosine bases of eukaryotic DNA, which are converted to 5methylcytosine by DNA methyl transferase (DNMT) enzymes. 5-methylcytosine, being detected, bonding to the N9H guanine in time determines what illnesses a patient may have such as cancer, Parkinson’s disease or Alzheimer (to name a few). The purpose of this research is to study the effects of methyl derivatives using the Density Functional Theory (B3LYP) to determine relative energy and to find the most reactive 5-methylated cytosine bonded to N9H guanine. Our research focuses on detecting the most reactive cytosine before it becomes carcinogenic or harmful and spreads throughout the body.

Funder Acknowledgement(s): National Science Foundation

Faculty Advisor: Noel Gardner,

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This material is based upon work supported by the National Science Foundation (NSF) under Grant No. DUE-1930047. Any opinions, findings, interpretations, conclusions or recommendations expressed in this material are those of its authors and do not represent the views of the AAAS Board of Directors, the Council of AAAS, AAAS’ membership or the National Science Foundation.