Classie Bradford - Hinds Community College-Utica Campus
Co-Author(s): Terra Dorsey and Zarah Drake, Jackson State University, Jackson, MS
Today, researchers know that DNA methylation occurs at the cytosine bases of eukaryotic DNA, which are converted to 5methylcytosine by DNA methyl transferase (DNMT) enzymes. 5-methylcytosine, being detected, bonding to the N9H guanine in time determines what illnesses a patient may have such as cancer, Parkinson’s disease or Alzheimer (to name a few). The purpose of this research is to study the effects of methyl derivatives using the Density Functional Theory (B3LYP) to determine relative energy and to find the most reactive 5-methylated cytosine bonded to N9H guanine. Our research focuses on detecting the most reactive cytosine before it becomes carcinogenic or harmful and spreads throughout the body.
Funder Acknowledgement(s): National Science Foundation
Faculty Advisor: Noel Gardner,