Discipline: Nanoscience or Materials Science
Subcategory: Materials Science
Jaylin McCollum - Jackson State University
Development of iron and manganese quantification method using magnetic resonance imaging relaxometer Jaylin A. Mccollum, Pohlee Cheah, Yongfeng Zhao* Department of Chemistry, Physics and Atmospheric Science, Jackson State University, Jackson, MS 39217, USAIron oxide nanoparticles (IOs) and manganese oxide (Mn3O4) have been receiving increasing attention due to their unique magnetism properties. They are widely used in different applications including separation/ purification, hyperthermia therapy, contrast agent for magnetic resonance imaging (MRI), and vesicle for targeted drug delivery and therapy. Recently, they emerge as a catalytic nanomaterial with intrinsic enzyme-like activities that further extended their novel applications. Many of the physical and chemical properties of these magnetic nanoparticles depends on its concentration to precisely interpret its effectiveness and efficiency. The concentration is also critical in terms of toxicity studies in biomedical applications. Therefore, the accurate quantification of Fe/Mn concentration is absolutely necessary. Currently, standard quantification method for Fe/Mn is using inductively coupled plasma (ICP) spectrometry for accurate analysis. However, ICP spectrometry is rather costly, requires high maintenance, and may not be easily accessible. In this paper, we report an alternative method to quantify Fe or Mn concentration using a benchtop magnetic resonance imaging (MRI) relaxometer. A standard curve of relaxation rate (1/Ti, s-1) versus Fe/Mn concentration, mM was obtained using different standard Fe/Mn ion source. IOs and Mn3O4 samples were first digested with acid and the relaxation rate were measured. The Fe/Mn concentration can be back calculated from the relaxivity calibration curve. The accuracy and sensitivity of this MRI method were verified by ICP method and Ferrozine-Fe assays method. The results showed that the MRI method is suitable to use for Fe concentration determination. The different iron sources dissolved in aqua regia have negligible effects on the relaxivities measurement. However, the relaxivities shifted when the using different acid solvents suggesting that the same acid solvent should be used to construct the standard curves and sample measurements. The undergoing research focuses on the determination of Mn concentration for Mn3O4 using MRI method. Keywords Magnetic resonance imaging relaxometer, Inductively coupled plasma analysis, Iron oxide, Manganese oxide, Iron/Manganese Quantification
Funder Acknowledgement(s): 1) NSF DMR-20001352) NSF DMR-2144790
Faculty Advisor: Yongfeng Zhao, email@example.com
Role: I was an active part in 100% of the research involved in this project.