Synthesis and Functionalization of Novel Iron Oxide Nanoparticles with Biocompatible Materials for Drug Delivery Applications

Graduate #34
Discipline: Chemistry and Chemical Sciences
Subcategory: Biochemistry (not Cell and Molecular Biology and Genetics)

JaNise Jackson - Clark Atlanta University
Co-Author(s): Idris Wazeerud-Din, John Melnyczuk, and Xiu R. Bu, Clark Atlanta University, Atlanta, GA

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The most common problem we face in treatments for disease is the lack of ability to directly target and effectively treat without harming healthy parts of the body. This research illustrates the use of iron oxide nanoparticles (IONPs) as valuable drug delivery vehicles to be used in targeted treatment therapies. The use of biocompatible materials such as chitosan that is readily found in nature (a derivative of chitin) will increase the ability for the nanoparticles to disperse and become soluble in water as well as allow for drug attachment and loading. IONPs functionalized with 3-aminopropyltrimthoxysilane, β-cyclodextrin and imidazopyridine compounds will increase bioavailability of IONPs and delivery of drugs. We have been able to synthesize and coat IONPs with biocompatible material aimed for a better and more sufficient method of drug delivery. Using XRD, FTIR, NMR, and thermal analysis, we have successfully characterized IONPs. The goal is to functionalize the IONPs with Imidazo compounds and create a dual coating system that will better serve in targeted drug delivery. In the future we hope to be able to determine drug loading capabilities and perform cell studies.

ERN ABSTRACT 10.1.2015.docx

Funder Acknowledgement(s): CREST

Faculty Advisor: Xiu Bu, jbu@cau.edu