Discipline: Chemistry and Chemical Sciences
Subcategory: Chemistry (not Biochemistry)
Marion D. Johnson - North Carolina Agricultural & Technical State University
Gold thiolate complexes are known agents in the treatment of arthritis, and preliminary studies have been done to identify possible antitumor and anti-malarial properties. A unique characteristic of gold is its high affinity for sulfur bonding resulting in numerous applications to these class of gold thiolate complexes. In this study the reactions of HAuCl4 with excess thiolate ligands of 1-adamantanethiol, 2-phenylethanethiol, and 3-methyl-1-butanethiol produced the multi-coordinate gold(III) thiolate complexes. The complexes represent a span of geometries as the sulfur ligands bind to the gold center in various ratios including mono-, bis-, tris-, and tetrakis- complexes. Characterizations of crystalline structures have been conducted using FT-IR, and Ramaen techniques as well as UV-Vis vis spectroscopy, NMR (13C & 1H), and single crystal X-ray diffraction. The details of these results will be presented. Future studies of these complexes include testing against Human Serum Albumin (HSA) to investigate its binding affinity to the plasma protein which accounts for 60% of blood and its role in drug delivery applications.
Not SubmittedFunder Acknowledgement(s): North Carolina Agricultural & Technical State University Department of Chemistry, NSF-LSAMP Bridge to Doctorate Fellowship
Faculty Advisor: Zerihun Assefa, zassefa@ncat.edu