Discipline: Technology and Engineering
Subcategory: Cancer Research
Room: Exhibit Hall A
Bryant S. Espino - El Camino College
Co-Author(s): Isley Alvarado, University of San Diego; Edwin Jimenez, Lawndale High School; Zhuyun Xiao, University of Los Angeles; Yilian Wang, University of Los Angeles; Mochanchandra K.P, University of Los Angeles; Gregory P. Carman, University of Los Angeles, Dino Di Carlo, University of Los Angeles; Rob N. Candler, University of Los Angeles.
Cell sorting has advanced biomedical research and cell therapy in relation to the isolation of different cell populations. The idea is that there is substantial medical analysis in terms of isolating cells and therapies in order to fight off particular illnesses. However, you cannot address each cell, doing so, one will have to control it using individual magnetic elements. Having an array of small magnetoelastic microdisks through microfluidic channels can enhance the separation process with accuracy. Precise control of specific cells in mass quantities is among one of the advantages of magnetic cell sorting . Yet, there remain additional room for improvement including the capability to capture and selectively release cells. So far, it has been demonstrated that magnetic-based cell sorting platform could quantitatively sort cells , but could not reach array-addressability. These platforms employ patterned soft micromagnets with magnetization controllable by external magnets, yet such methods could not achieve array-addressable control and may suffer from joule heating. In this work, we propose to employ highly magnetoelastic Terfenol-D microdisks that function as the key building block of a multiferroic-based cell-sorting platform. The magnetization states of individual Terfenol-D disks could be locally tuned and controlled by an electric field applied through a piezoelectric substrate. The patterned micromagnet arrays thus interact locally and non-destructively with individual magnetically-tagged cells. A series of measurements were performed to examine the structural and magnetic properties of Terfenol-D microdisks of 20 μm in diameter. Superconducting quantum interference device is used to acquire the magnetic hysteresis loop of the Terfenol-D thin film. X-ray absorption spectroscopy and x-ray magnetic circular dichroism (XMCD) provides elemental magnetic properties at the surface and in the bulk film. Lastly, magnetic contrast imaged by XMCD-PEEM (photoemission electron microscopy) reveals a single magnetic domain in the microdisk. These measurements represent advanced methods to move closer to building energy-efficient, array-addressable and compact multiferroic-based cell sorting devices. It also exhibits how ideal Terfenol-D is when releasing and capturing cells. To further the research, the implementation of microfluidic channels is needed to manipulate the interaction between the magnetic beads and the microstructures.
Funder Acknowledgement(s): National Science Foundation
Faculty Advisor: Maggie Xiao, firstname.lastname@example.org
Role: I focused more on finding out if the Terfenol-D was fully functional through special techniques such as spectropsy, XMCD, and SQUID in order to study the elements within the material and its properties.