Emerging Researchers National (ERN) Conference

nsf-logo[1]

  • About
    • About AAAS
    • About the NSF
    • About the Conference
    • Partners/Supporters
    • Project Team
  • Registration
    • Conference Registration
    • Exhibitor Registration
    • Hotel Reservations
  • Abstracts
    • Abstract Submission Process
    • Presentation Schedules
    • Abstract Submission Guidelines
    • Presentation Guidelines
    • Undergraduate Abstract Locator (2020)
    • Graduate Abstract Locator (2020)
    • Faculty Abstract Locator (2020)
  • Travel Awards
  • Resources
    • App
    • Award Winners
    • Code of Conduct-AAAS Meetings
    • Code of Conduct-ERN Conference
    • Conference Agenda
    • Conference Materials
    • Conference Program Books
    • ERN Photo Galleries
    • Events | Opportunities
    • Exhibitor Info
    • HBCU-UP/CREST PI/PD Meeting
    • In the News
    • NSF Harassment Policy
    • Plenary Session Videos
    • Professional Development
    • Science Careers Handbook
    • Additional Resources
    • Archives
  • Engage
    • Webinars
    • Video Contest
    • Video Contest Winners
    • ERN 10-Year Anniversary Videos
    • Plenary Session Videos
  • Contact Us
  • App View

Fibrosis Developmental Mechanisms in the Type 2 Diabetic Liver

Undergraduate #48
Discipline: Biological Sciences
Subcategory: Cell and Molecular Biology

Fabiola A. Juárez Jaramillo - California State University Los Angeles
Co-Author(s): Katrina Go Yamazaki, California State University Los Angeles



Type 2 Diabetes (T2D) hepatic effects are macrovesicular lipid accumulation, inflammation, and injury leading to hepatic fibrosis [2]. Activated hepatic stellate cells (HSC) have been associated with an unbalanced synthesis of fibrillar collagens (I and III) and extracellular matrix (ECM) degradation by matrix metalloproteinase (MMPs) in particular, MMP-2 and MMP-9 [3]. Therefore, inflammatory cytokines identification and MMPs enzymatic activity levels on the onset of T2D-induced rat models is crucial. Thus, two specific aims: 1) to investigate MMP-2 and MMP-9 enzymatic activity levels and 2) to identify TNF-α inflammatory cytokine expression in liver tissue. In vivo Sprague Dawley rat models included controls and T2D-induced by High Energy Diet (HED). Results of western analysis showed no TNF-α expression and analysis of gelatin Zymography MMP-2 and MMP-9 showed no significant difference between control and diabetic liver tissue. Future studies: western analysis optimization, interleukin 1 (IL-1) cytokine analysis to further assess inflammation, liver tissue staining to assess hepatic lipid content, and TGF-β1 pro-fibrogenic cytokine analysis.

Funder Acknowledgement(s): Minority Biomedical Research Support Program-Research Initiative for Scientific Enhancement (MBRS-RISE) part of Minority Opportunities in Research (MORE). Grant Number: GM061331.

Faculty Advisor: Katrina Yamazaki,

ERN Conference

Celebrating 10 years of ERN!

What’s New

  • Webinars
  • Events|Opportunities
  • AAAS CEO Comments on Social Unrest, Racism, and Inequality
  • Maintaining Accessibility in Online Teaching During COVID-19
  • In the News
  • #ShutDownSTEM
  • HBCU/CREST PI/PD Meeting

Conference Photos

ERN Conference Photo Galleries

Awards

ERN Conference Award Winners

Checking In

Navigation

  • About the ERN Conference
  • Partners/Supporters
  • Abstracts
  • Travel Awards
  • Conference Registration
  • Exhibitor Registration
  • Hotel Reservations

nsf-logo[1]

This material is based upon work supported by the National Science Foundation (NSF) under Grant No. DUE-1930047. Any opinions, findings, interpretations, conclusions or recommendations expressed in this material are those of its authors and do not represent the views of the AAAS Board of Directors, the Council of AAAS, AAAS’ membership or the National Science Foundation.

AAAS

1200 New York Ave, NW Washington,DC 20005
202-326-6400
Contact Us
About Us

The World's Largest General Scientific Society

Useful Links

  • Membership
  • Careers at AAAS
  • Privacy Policy
  • Terms of Use

Focus Areas

  • Science Education
  • Science Diplomacy
  • Public Engagement
  • Careers in STEM

 

  • Shaping Science Policy
  • Advocacy for Evidence
  • R&D Budget Analysis
  • Human Rights, Ethics & Law
© 2021 American Association for the Advancement of Science