Discipline: Chemistry and Chemical Sciences
Room: Park Tower 8219
Kimberly Fenin - Howard University
Co-Author(s): Sabrina Pierre- Howard University, Washington, DC
The search of an efficient and cost-effective form of drug delivery continues to be prioritized in the world of research. Amoxicillin (C16H19N3O5S) is an antibiotic most commonly used for bacterial infections such as chest/lung infections, oral infections, Urinary Tract Infections, etc. It is a water-soluble compound at 3.43 g/L, with a molecular weight of 365.404 g/mol. Using polymers is important in advancing controlled release of a drug. In this paper, we explain the influence of polyethyleneimine (PEI), a colloidal cationic polymer, for evenly coating magnetic nanoparticles (MNPs) synthesized from Iron (III) Oxide (Fe3O4). PEI remains highly used in clinical trials due to its high transfection. MNPs have earned a major role in drug delivery because of their small size, large surface area and easy manipulation through the body. PEI-coated MNPs were then functionalized with Amoxicillin, verified through FTIR spectroscopy, UV-Vis Spectroscopy, X-Ray Diffraction, and Transmission Electron Microscopy altogether helped to abed in explaining results of a moderate, more steady release of the Amoxicillin drug.
Funder Acknowledgement(s): Dr. Titinchi
Faculty Advisor: Sharon Evans, email@example.com
Role: I took part In the research, analysis, experimental and presentation of this topic.