• Skip to main content
  • Skip to after header navigation
  • Skip to site footer
ERN: Emerging Researchers National Conference in STEM

ERN: Emerging Researchers National Conference in STEM

  • About
    • About AAAS
    • About the NSF
    • About the Conference
    • Partners/Supporters
    • Project Team
  • Conference
  • Abstracts
    • Undergraduate Abstract Locator
    • Graduate Abstract Locator
    • Abstract Submission Process
    • Presentation Schedules
    • Abstract Submission Guidelines
    • Presentation Guidelines
  • Travel Awards
  • Resources
    • Award Winners
    • Code of Conduct-AAAS Meetings
    • Code of Conduct-ERN Conference
    • Conference Agenda
    • Conference Materials
    • Conference Program Books
    • ERN Photo Galleries
    • Events | Opportunities
    • Exhibitor Info
    • HBCU-UP/CREST PI/PD Meeting
    • In the News
    • NSF Harassment Policy
    • Plenary Session Videos
    • Professional Development
    • Science Careers Handbook
    • Additional Resources
    • Archives
  • Engage
    • Webinars
    • ERN 10-Year Anniversary Videos
    • Plenary Session Videos
  • Contact Us
  • Login

Determining a Role for Porphoryn-Like Compunds During Glucagon Like Peptide-1 Induced Adipogenesis Which Invludes the Down-Regulation of the Gene Encoding Hes-1

Undergraduate #86
Discipline: Biological Sciences
Subcategory: Genetics

Shunsey Brooks - Savannah State University
Co-Author(s): Johnny Johnson, Savannah State University, Savannah, GA



Previous data confirms that 3T3-L1 cells contain endogenous Notch receptors that can be activated by a ligand (Ross D. et al., 2004). Because Hes-1 is a direct target of the Notch signaling pathway, it has been proposed that Notch signaling inhibits adipogenesis by stimulating and maintaining Hes-1 expression (Ross D. et al., 2004). The mechanism by which Hes-1 blocks differentiation, however, is not clear. Hes-1 acts distal to CCAAT/enhancer binding protein (C/EBP), beta (C/EBPβ) induction and prior to or at the point of peroxisome proliferatoractivated receptors (PPARγ) and C/EBPα induction (Ross D. et al., 2004). Discovering that the Hes-1 block can be rescued by either C/EBPα or PPARγ suggests that Hes-1 does not affect the activity of either of these transcription factors (Ross D. et al., 2004). In summary, the proposed study is to determine the effect of Porphoryn-Like compounds on GLP-1 induced adipogenesis, using 3T3 L-1 preadipocytes, and to determine if Porphoryn-Like compounds are involved in endogenous notch cleavage so that Hes-1 is down-regulated in order for differentiation to take place.

Funder Acknowledgement(s): NSF-MAGEC-STEM

Faculty Advisor: Johnny Johnson,

Sidebar

Abstract Locators

  • Undergraduate Abstract Locator
  • Graduate Abstract Locator

This material is based upon work supported by the National Science Foundation (NSF) under Grant No. DUE-1930047. Any opinions, findings, interpretations, conclusions or recommendations expressed in this material are those of its authors and do not represent the views of the AAAS Board of Directors, the Council of AAAS, AAAS’ membership or the National Science Foundation.

AAAS

1200 New York Ave, NW
Washington,DC 20005
202-326-6400
Contact Us
About Us

  • LinkedIn
  • Facebook
  • Instagram
  • Twitter
  • YouTube

The World’s Largest General Scientific Society

Useful Links

  • Membership
  • Careers at AAAS
  • Privacy Policy
  • Terms of Use

Focus Areas

  • Science Education
  • Science Diplomacy
  • Public Engagement
  • Careers in STEM

Focus Areas

  • Shaping Science Policy
  • Advocacy for Evidence
  • R&D Budget Analysis
  • Human Rights, Ethics & Law

© 2023 American Association for the Advancement of Science