Development of Novel Tetrahydroimidazopyridine and their Antiproliferative Property Against Prostate Cancer

Undergraduate #160
Discipline: Chemistry and Chemical Sciences
Subcategory: Cancer Research

Dontá Samuel - Clark Atlanta University
Co-Author(s): Idris Wazeerud-Din and Xiu R. Bu, Clark Atlanta University, Atlanta, GA

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Many drugs contain imidazole moiety, and likewise, many imidazole compounds have important biological properties. The development of imidazole derivatives becomes a part of efforts in the cancer drug discovery research. We have previously developed novel classes of imidazopyridines (IMP) and also demonstrated that they possess promising antiproliferative properties against castration-resistant prostate cancer cells. Here we extend our study to the reduced form of imidazopyridine to prepare a new class of tetrahydroimidazopyridines (THIP). THIP consists of a five-membered imidazole ring fused with a six-membered heterocyclic piperidine ring. The difference between THIP and IMP is that THIP has piperidine ring while IMP has pyridine ring instead. This new structural feature offers us an opportunity to explore unique property against prostate cancer cells. Currently, we have developed several THIPs through the reduction of IMPs. One of the compound, 1,3-diphenyltetrahydroimidazopyridine has been evaluated for antiproliferative property. It has displayed promising effectiveness against prostate cancer cell lines (PC3). Our goal of this project is to optimize the condition to synthesize novel THIP derivatives, then create a library of compounds for the structural investigation of their antiproliferative properties against PC3 cells.

Funder Acknowledgement(s): CCRTD, LSAMP, and NSF

Faculty Advisor: James Bu, Jbu@cau.edu

Role: Characterization of the imidazopyridine and using nmr (nuclear magnetic resonance) to show the sifts of the THIP. Basically the bulk of my abstract was my research.