Discipline: Chemistry and Chemical Sciences
Subcategory: Biochemistry (not Cell and Molecular Biology and Genetics)
Room: Exhibit Hall A
Brianna Burton - Xavier University of Louisiana
Co-Author(s): Surah Srinivas, Brooke Nguyen, Dr. Amit Nautiyal, Dr. Zhe Wang, Xavier University of Louisiana, New Orleans, Louisiana
In the medical field, patients are generally given synthetic opioids for pain relief. Of these synthetic opioids, Fentanyl has become the most extensively used synthetic opioid in medicine as of 2017. Its prevalence stems from its various uses in anesthesia, management of chronic pain, and rehabilitation for opioid addiction. Despite its promising applications, many patients still experience adverse effects due to receiving standard doses rather than individualized dosage. Even though present sensors are able to identify the presence of Fentanyl, they are expensive and unable to measure levels of Fentanyl in bodily fluids. With a sensor capable of directly measuring Fentanyl concentrations, physicians will be able to tailor treatments and deliver personalized doses based on the patient?s health. In this study, an electrochemical technique was used to plate arginine-modified polyaniline on a gold surface to detect Fentanyl for point-of-care diagnosis. Based on these results, the new method would allow for a more efficient and cost-effective strategy to utilize Fentanyl and other medications.
Funder Acknowledgement(s): This work is supported by funding from the Army Research Office under Grant Number W911NF-18-1-0458, National Science Foundation (CHE-1832167; HRD-1700429 and MCB-1830866), NIMHD-RCMI ; (5G12MD007595) and NIGMS-BUILD (8UL1GM118967).
Faculty Advisor: Dr. Zhe Wang, firstname.lastname@example.org
Role: I replicated multiple experiments by performing Potentiostatic EIS on various concentrations of Fentanyl mixed in a solution of 16.67% human serum, 5 milliliters of Phosphate-Buffered Saline (PBS), and 0.500 grams of L-Arginine, and Polyaniline. Along with this solution, I also performed Potentiostatic EIS on various concentrations of Fentanyl in a solution of 12.50% human serum, 5 milliliters of PBS, and 0.500 grams of L-Arginine. Using electrochemical technique, arginine-modified Polyaniline was plated onto a gold surface to contribute to the sensitivity and selectivity of Polyaniline with the Fentanyl.