• Skip to main content
  • Skip to after header navigation
  • Skip to site footer
ERN: Emerging Researchers National Conference in STEM

ERN: Emerging Researchers National Conference in STEM

  • About
    • About AAAS
    • About the NSF
    • About the Conference
    • Partners/Supporters
    • Project Team
  • Conference
  • Abstracts
    • Undergraduate Abstract Locator
    • Graduate Abstract Locator
    • Abstract Submission Process
    • Presentation Schedules
    • Abstract Submission Guidelines
    • Presentation Guidelines
  • Travel Awards
  • Resources
    • Award Winners
    • Code of Conduct-AAAS Meetings
    • Code of Conduct-ERN Conference
    • Conference Agenda
    • Conference Materials
    • Conference Program Books
    • ERN Photo Galleries
    • Events | Opportunities
    • Exhibitor Info
    • HBCU-UP/CREST PI/PD Meeting
    • In the News
    • NSF Harassment Policy
    • Plenary Session Videos
    • Professional Development
    • Science Careers Handbook
    • Additional Resources
    • Archives
  • Engage
    • Webinars
    • ERN 10-Year Anniversary Videos
    • Plenary Session Videos
  • Contact Us
  • Login

Fenton Reaction Damaging Effects on Biological Molecules: A Theoretical Study

Graduate #36
Discipline: Chemistry and Chemical Sciences
Subcategory: Biochemistry (not Cell and Molecular Biology and Genetics)

Sharnek Walker - Jackson State University
Co-Author(s): Glake Hill, Jackson State University, Jackson, MS



The human body is introduced to metal ions through ingestion of contaminated foods and water, direct contact or injection. The toxic metal ions can be harmful to the human body and cause diseases like Alzheimer’s disease and cancer. Metals, like iron, are present in the body, but in excess levels the effects of these metals could be detrimental to biological molecules and the functioning processes. For example, the metal ions can cause the production of reactive oxygen species (ROS), thus causing oxidative stress to biological molecules, like deoxyribonucleic acid (DNA). The Fenton reaction produces the hydroxyl radical, which is a ROS that is detrimental to the human body. Understanding the spontaneity of the different nucleobases interacting with the hydroxyl radical to produce mutated bases can help in limiting the damage caused to DNA. Employing computational approaches provides a method for answering these unknowns that are less expensive and time consuming than traditional experimental approaches. In addition, computational data may help direct future experimental investigations. Traditional DFT methods were employed to investigate the interaction between the DNA bases and hydroxyl radicals produced from the Fenton reaction. Energy values were compared to previous theoretical literature and are in good agreement with the studied reactions. Future studies will include solvent models to simulate biological molecules in the body.

Not Submitted

Funder Acknowledgement(s): Title III Graduate Fellowship Program NSF-CREST Interdisciplinary Center for Nanotoxicity at Jackson State University.

Faculty Advisor: Glake Hill, glakeh@icnanotox.org

Sidebar

Abstract Locators

  • Undergraduate Abstract Locator
  • Graduate Abstract Locator

This material is based upon work supported by the National Science Foundation (NSF) under Grant No. DUE-1930047. Any opinions, findings, interpretations, conclusions or recommendations expressed in this material are those of its authors and do not represent the views of the AAAS Board of Directors, the Council of AAAS, AAAS’ membership or the National Science Foundation.

AAAS

1200 New York Ave, NW
Washington,DC 20005
202-326-6400
Contact Us
About Us

  • LinkedIn
  • Facebook
  • Instagram
  • Twitter
  • YouTube

The World’s Largest General Scientific Society

Useful Links

  • Membership
  • Careers at AAAS
  • Privacy Policy
  • Terms of Use

Focus Areas

  • Science Education
  • Science Diplomacy
  • Public Engagement
  • Careers in STEM

Focus Areas

  • Shaping Science Policy
  • Advocacy for Evidence
  • R&D Budget Analysis
  • Human Rights, Ethics & Law

© 2023 American Association for the Advancement of Science